References
In addition to embedded links throughout the website,for further reading please review the following references, also linked to original source material where possible.
1. US Census Bureau, He W, et al. Shades of Gray: A Cross-Country Study of Health and Well-Being of the Older Populations in SAGE Countries, 2007–2010, P95/12-0, May 2012.
2. Baker DJ, et al. clearance of p16ink4a-positive senescent cells delays ageing-associated disorders. Nature 2011; 479:232-6.
3. Conboy IM, et al. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 2005;433:760-4.
4. Villeda SA, et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 2011;477:90-4.
5. Song Z, et al. Alterations of the systemic environment are the primary cause of impaired B and T lymphopoiesis in telomere-dysfunctional mice. Blood 2010;115:1481-9.
6. Conboy MJ, et al. Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity. Aging Cell 2013;12:525-30.
7. Katsimpardi L, et al. Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors. Science May, 2014; vol 344, no 6184:630-634.
8. Sinha M, et al. Restoring Systemic GDF11 Levels Resverses Age-Related Dysfunction in Mouse Skeletal Muscle. Science May, 2014; vol 344 no 6184:649-652.
9. Villeda S, et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nature 2014;20:659-663.
10. McLeod B, et al. Apheresis: Principles and Practice 3rd Edition; AABB Press 2010; 1:688.
11. Kiprov D, et al. The effect of plasmapheresis and drug immunosuppression on T-cell subsets as defined by monoclonal antibodies. J Clni Apher 1983;1(2):57-63.
12. Giacchino F, et al. Plasmapheresis influences the immune response affecting T cell subsets. Life Support Syst. 1983;1 Suppl 1:118-21.
13. Fiorini G, et al. Modifications in Peripheral blood Lymphocyte Subpopulations Induced by Plasmapheresis and Immunosuppressive Drugs. Plasma Ther Transfus Technol 1982; 3:389-393.
14. Bonomini V, et al. Effect of plasmapheresis on cellular immunity abnormablities in patients with systemic lupus erythematosus. Clin Nephrol. 1984 Sep;22(3):121-6.
15. Soltesz P, et al. Plasmapheresis modulates Th1/Th2 imbalance in patient with systemic lupus erythematosus according to measurement of intracytoplasmic cytokines. Autoimmunity, 2002 Feb;35(1):51-6.
16. Barath S, et al. The severity of systemic lupus erythematosus negatively correlates with the increasing number of CD4+CD25(high)FoxP3+regulatory T cells during repeated plasmapheresis treatments of patients. Autoimmunity, 2007 Nove;40(7):521-8.
17. Bainbridge DR, et al. Can repeated plasma donation by asymptomatic HIV-infected individuals delay the onset of AIDS? Philos Trans R Soc Lond B Biol Sci. 1997 Jul 29;352(1355):763-70.
18. Kiprov D, et al. Intermittent Heterochronic Plasma Exchange as a Modality for Delaying Cellular Senescence – A Hypotheses. J Clin Apheresis 2013;28:387-389.
19. Kiprov D, et al. Adverse Reactions Associated With Mobile Therapeutic Apheresis:Analysis of 17,940 Procedures. J Clin Apheresis 2001;16:130-133.
20. Pandey S, et al. Adverse effects of plasma transfusion. Transfusion 2012 May;52 Suppl 1:65S-79S.
21. Age Distribution of Blood Donors by Country. WHO Global Database on Blood Safety. 2008 (updated 2011).
22. Taverna M, et al. Specific antioxidant properties of human serum albumin. Ann Intensive Care 2013;3:4.
23. Sharief MK, et al. I.v. immunoglobulin reduces circulating proinflammatory cytokines in Guillain-Barre syndrome. Neurology 1999;52:1833-8.
24. Rebo J, et al. A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood. Nature Communications 2016;1038-13363.
25. Simon, K.A., et al. Evolution of the immune system in humans from infancy to old age. Proc Biol Sci 2015 Dec 22; 282(1821): 20143085.
26. Chung, H.Y., et al. Molecular Inflammation: Underpinnings of Aging and Age-related Diseases. Ageing Res Rev. 2009 Jan; 8(1): 18-30.
27. Paez, A. et al. The AMBAR trial: an interim analysis. ASFA Annual Meeting 2016
28. Paez, A. et al., Grifols AMBAR results demonstrate a significant reduction in the progression of moderate Alzheimer's Disease. Clinical Trials on Alzheimer's Disease (CTAD) congress on October 27, 2018 in Barcelona
In addition to embedded links throughout the website,for further reading please review the following references, also linked to original source material where possible.
1. US Census Bureau, He W, et al. Shades of Gray: A Cross-Country Study of Health and Well-Being of the Older Populations in SAGE Countries, 2007–2010, P95/12-0, May 2012.
2. Baker DJ, et al. clearance of p16ink4a-positive senescent cells delays ageing-associated disorders. Nature 2011; 479:232-6.
3. Conboy IM, et al. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 2005;433:760-4.
4. Villeda SA, et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 2011;477:90-4.
5. Song Z, et al. Alterations of the systemic environment are the primary cause of impaired B and T lymphopoiesis in telomere-dysfunctional mice. Blood 2010;115:1481-9.
6. Conboy MJ, et al. Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity. Aging Cell 2013;12:525-30.
7. Katsimpardi L, et al. Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors. Science May, 2014; vol 344, no 6184:630-634.
8. Sinha M, et al. Restoring Systemic GDF11 Levels Resverses Age-Related Dysfunction in Mouse Skeletal Muscle. Science May, 2014; vol 344 no 6184:649-652.
9. Villeda S, et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nature 2014;20:659-663.
10. McLeod B, et al. Apheresis: Principles and Practice 3rd Edition; AABB Press 2010; 1:688.
11. Kiprov D, et al. The effect of plasmapheresis and drug immunosuppression on T-cell subsets as defined by monoclonal antibodies. J Clni Apher 1983;1(2):57-63.
12. Giacchino F, et al. Plasmapheresis influences the immune response affecting T cell subsets. Life Support Syst. 1983;1 Suppl 1:118-21.
13. Fiorini G, et al. Modifications in Peripheral blood Lymphocyte Subpopulations Induced by Plasmapheresis and Immunosuppressive Drugs. Plasma Ther Transfus Technol 1982; 3:389-393.
14. Bonomini V, et al. Effect of plasmapheresis on cellular immunity abnormablities in patients with systemic lupus erythematosus. Clin Nephrol. 1984 Sep;22(3):121-6.
15. Soltesz P, et al. Plasmapheresis modulates Th1/Th2 imbalance in patient with systemic lupus erythematosus according to measurement of intracytoplasmic cytokines. Autoimmunity, 2002 Feb;35(1):51-6.
16. Barath S, et al. The severity of systemic lupus erythematosus negatively correlates with the increasing number of CD4+CD25(high)FoxP3+regulatory T cells during repeated plasmapheresis treatments of patients. Autoimmunity, 2007 Nove;40(7):521-8.
17. Bainbridge DR, et al. Can repeated plasma donation by asymptomatic HIV-infected individuals delay the onset of AIDS? Philos Trans R Soc Lond B Biol Sci. 1997 Jul 29;352(1355):763-70.
18. Kiprov D, et al. Intermittent Heterochronic Plasma Exchange as a Modality for Delaying Cellular Senescence – A Hypotheses. J Clin Apheresis 2013;28:387-389.
19. Kiprov D, et al. Adverse Reactions Associated With Mobile Therapeutic Apheresis:Analysis of 17,940 Procedures. J Clin Apheresis 2001;16:130-133.
20. Pandey S, et al. Adverse effects of plasma transfusion. Transfusion 2012 May;52 Suppl 1:65S-79S.
21. Age Distribution of Blood Donors by Country. WHO Global Database on Blood Safety. 2008 (updated 2011).
22. Taverna M, et al. Specific antioxidant properties of human serum albumin. Ann Intensive Care 2013;3:4.
23. Sharief MK, et al. I.v. immunoglobulin reduces circulating proinflammatory cytokines in Guillain-Barre syndrome. Neurology 1999;52:1833-8.
24. Rebo J, et al. A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood. Nature Communications 2016;1038-13363.
25. Simon, K.A., et al. Evolution of the immune system in humans from infancy to old age. Proc Biol Sci 2015 Dec 22; 282(1821): 20143085.
26. Chung, H.Y., et al. Molecular Inflammation: Underpinnings of Aging and Age-related Diseases. Ageing Res Rev. 2009 Jan; 8(1): 18-30.
27. Paez, A. et al. The AMBAR trial: an interim analysis. ASFA Annual Meeting 2016
28. Paez, A. et al., Grifols AMBAR results demonstrate a significant reduction in the progression of moderate Alzheimer's Disease. Clinical Trials on Alzheimer's Disease (CTAD) congress on October 27, 2018 in Barcelona
